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Case study of amyloidosis

Manifestations of Pompe disease — its suspected signs or symptoms — can mimic diagnostic findings of a rare type of amyloidosis , a case study reports. The patient, a year-old woman, had a three-year history of progressive symptoms. She started by experiencing increased salivation, which was followed by slurred speech dysarthria , difficulty swallowing dysphagia , enlargement of the tongue macroglossia , and reduced ability to taste things hypogeusia. After an initial evaluation from her primary care doctor, she received a brain magnetic resonance imaging MRI scan to rule out a stroke. The test was negative. Given the progressive nature of her symptoms affecting muscle response, the clinical team suspected myasthenia gravis — an autoimmune disease caused by impaired communication between nerves and muscles.

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Case Study: GI Bleed in a Patient with Amyloidosis - darma.info

History noted that the ulcerated plaque was a squamous cell carcinoma or an infection. Histologically, there was no evidence of neoplasia or infection. The microscopic lesions consisted of severe hyperplasia of the nasal mucosa. The submucosa exhibited fibrosis, areas of mild hemorrhage, moderate to large numbers of hemosiderin-laden macrophages, moderate infiltration of lymphocytes and plasma cells, and focal moderate mineralization of the connective tissue and the wall of small arteries.

Case Study: GI Bleed in a Patient with Amyloidosis

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A board-style question with an explanation and a link to a relevant article is a recurring feature of TraineE-News. The goal of the case study is to clarify specific and timely teaching points in the field of hematology. The following case study focuses on a year-old male who is seen by his cardiologist for a new restrictive cardiomyopathy. He is found to also have an elevated serum creatinine, and, with concern for amyloidosis, the patient undergoes a fat pad biopsy. Pathologic evaluation displays apple-green birefringence under polarized light when stained with Congo red dye.

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