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Indian Premier League: A Controversially Successful Sporting Event
Immunotherapy Case Study: Treatment Monitoring in Cancer
Background: Deep sequencing of lymphocyte receptor repertoires has made it possible to comprehensively profile the clonal composition of lymphocyte populations. This opens the door for novel approaches to diagnose and prognosticate diseases with a driving immune component by identifying repertoire sequence patterns associated with clinical phenotypes. Indeed, recent studies support the feasibility of this, demonstrating an association between repertoire-level summary statistics e. In our own prior work, we have shown that six codons in VH4-containing genes in B cells from the cerebrospinal fluid of patients with relapsing remitting multiple sclerosis RRMS have higher replacement mutation frequencies than observed in healthy controls or patients with other neurological diseases. However, prior methods to date have been limited to focusing on repertoire-level summary statistics, ignoring the vast amounts of information in the millions of individual immune receptors comprising a repertoire. We have developed a novel method that addresses this limitation by using innovative approaches for accommodating the extraordinary sequence diversity of immune receptors and widely used machine learning approaches. We applied our method to RRMS, an autoimmune disease that is notoriously difficult to diagnose.
Perspectives to develop a repertoire of pedagogical strategies
Student 1 is an unintelligible female speaker with a very limited phonetic repertoire, severe pitch and loudness problems and little residual hearing. She was not using amplification when she sought speech-language services but expressed a willingness to explore the use of hearing aids and computerized visual feedback equipment to facilitate instruction, practice and self-monitoring. Student 1 made modest gains in pitch control, speech sound production and intelligibility after 20 hours of individual instruction. Rated as 1. NTID Voice Evaluation : Severe vocal tension which at times results in inability to sustain phonation; severe problem coordinating respiration and phonation; severe problem with prosody blending and co-articulation ; loudness was much below appropriate intensity levels.
Here you can explore case studies drawn from a wide range of contexts , including school classrooms, early years settings and community locations. There are examples of inspiring work with children and young people that ranges from babies to older teenagers, led by classroom teachers, community musicians, instrumental tutors and other practitioners. These cases have each been included because they are examples of effective learning and teaching — they tell local stories in which positive outcomes are achieved. They are not meant to be comprehensive of all effective practice across the country, but rather to offer examples that illustrate the likely nature of this effective practice. The cases represent an initial set; over time we hope to add and expand these to illustrate further the rich diversity that characterises effective music education in England.