What are the essential parts of a signaling pathway? How could activating a transcription factor cause long-term cellular changes? What roles can phosphorylation play in protein function? What is the enzymatic activity of a kinase and of a phosphatase? What determines where a protein kinase or protein phosphatase will perform its enzymatic activity?
Diabetes and Insulin Signaling
Diabetes and Insulin Signaling Case Study | Signal Transduction | Cell Signaling
Diabetics in mid-life carry a 1. Metabolic syndrome MetS , a type 2 diabetes T2D precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function . These critical nutrient sensing pathways modulate epigenetic shifts in the genome by channeling fuel substrates either towards mitochondrial fatty acid oxidation AMPK or cytosolic glycolysis and substrate level phosphorylation mTOR . This case study was designed to examine the link between peripheral insulin resistance and early stage memory loss in a type 2 diabetic male. Reactivating the AMPK pathway via induced and controlled nutritional ketosis combined with high intensity interval training HIIT in order to inhibit mTOR signaling were primary features of the 10 week intervention.
Diabetes And Insulin Signaling Case Study Answers
In this just released case study, physicians are actually reversing insulin-dependent Type II diabetes with intermittent fasting. While this is an observational study, with only 3 patients, the turn around was remarkable and worth considering for your practice. In his book, Dr.